5C Richard Hutchinson
Summary for 2004 [at-glance overview of C Richard Hutchinson work for the selected year as suggested by data mining algorithms]
This is an Authoratory overview of author C Richard Hutchinson. According to available data, in 2004 C Richard Hutchinson published at least 5 articles. This work was completed in collaboration with several authors including Licari, Peter and Hu, Zhihao. Many other authors have collaborated with C Richard Hutchinson as well. At least 24 different grants are awarded to C Richard Hutchinson to support this work. All time total of the grant awards on file exceeds $10,024,373.
C Richard Hutchinson has rank 13 when compared to all other authors using the keyword Erythromycin. Analysis of the article abstracts and the titles suggests that C Richard Hutchinson professional interests are focused around "tetracenomycin f2 cyclase", "classically improved strains" and "megalomicin erythromycin polyketide". These might also be referred to as "strain b9", "meg pks" or "functional analysis". Statistical analysis shows that C Richard Hutchinson's writing is likely to contains terms "polyketide", "production", "debs", "strain", "strains" and "15-methyl-6-deb".
The majority of C Richard Hutchinson articles are affiliated with Kosan Biosciences, Inc., 3832 Bay Center Place Hayward, CA California 94545 USA. Luckily, several email addresses are on file.
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Year 2004 Charts [C Richard Hutchinson frequent coauthors and the most common unique vocabulary terms for the selected year]
Historical Performance Charts [graphical overview of C Richard Hutchinson publication and funding history for the range of years]
Emails (3) [email addresses extracted from C Richard Hutchinson affiliations]
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C Richard Hutchinson Coauthors (15) [all coauthors with the number of joint publications]
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Affiliations (3) [condensed summary of the C Richard Hutchinson affiliations, the leading number and the color conveys importance]
- 3Kosan Biosciences, Inc., 3832 Bay Center Place Hayward, CA California 94545 USA.
1Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
1Department of Chemical Engineering, MC 5025, Stanford University, CA 94305, USA.
Key Opinion Leader In [C Richard Hutchinson is considered a key opinion leader in any keyword where the rank of 5 is achieved, the leading number before the keyword shows the author's rank as compared to all other authors]
- 13Erythromycin | 17Streptomyces
Keywords (32) [keywords assigned to C Richard Hutchinson articles by PubMed, the leading number and the color conveys importance]
- 4Streptomyces | 3Erythromycin | 2Genetic Enhancement | 2Anti-Bacterial Agents | 2Bacterial Proteins | 2Gene Expression Regulation, Bacterial | 1Mutagenesis | 1Base Sequence | 1Saccharopolyspora | 1Drug Industry | 1Pharmaceutical Preparations | 1Cell Line, Tumor | 1Crystallography, X-Ray | 1Catalysis | 1Bioreactors | 1DNA Primers | 1Benzoquinones | 1Protein Conformation | 1Species Specificity | 1Aminoglycosides | 1Humans | 1Pilot Projects | 1Antibiotics, Antineoplastic | 1Isomerases | 1Quinones | 1Protein Structure, Tertiary | 1Genome, Bacterial | 1Polyketide Synthases | 1Cell Culture Techniques | 1Gene Expression Profiling | 1Aldehyde-Lyases | 1Actinobacteria
C Richard Hutchinson Unique Vocabulary (96) [single words, word pairs and phrases obtained by analysis of abstracts and titles, the leading number and the color conveys importance; C Richard Hutchinson might be a good expert witness on these terms]
- 12polyketide | 11production | 10debs | 9strain | 8strains | 715-methyl-6-deb | 7improved | 7geldanamycin | 66-deb | 6genes | 6meg | 6analogues | 6erythromycin | 6process | 5analysis | 5cyclase | 4biosynthetic | 4structural | 4novel | 4gene | 4engineered | 4fradiae | 4pks | 4within | 4productivity | 4streptomyces | 4enzyme | 4hybrid | 3diketide | 3pkss | 3b9 | 3precursor
- 3strain b9 | 3meg pks | 3functional analysis | 3classically improved | 3geldanamycin analogues | 3streptomyces glaucescens | 3tetracenomycin f2 | 3escherichia coli | 3improved strains | 3combining classical | 3f2 cyclase | 2hybrid debs | 2pks genes | 2active site | 2ii polyketide | 2diketide precursor | 2mutant debs | 2classical genetic | 2strategies improved | 2hygroscopicus am-3672 | 2analysis tetracenomycin | 26-deoxyerythronolide analogues | 2genetic process | 2novel geldanamycin | 2type ii | 2process strategies | 2structural functional | 2improved precursor-directed | 2cyclase streptomyces | 2production 6-deoxyerythronolide | 2gene cluster | 2am-3672 type
- 3tetracenomycin f2 cyclase | 3classically improved strains | 3megalomicin erythromycin polyketide | 2isolation characterization novel | 2classical genetic process | 2f2 cyclase streptomyces | 2meg pks genes | 2novel geldanamycin analogues | 2production 6-deoxyerythronolide analogues | 2characterization novel geldanamycin | 2functional analysis tetracenomycin | 2combining classical genetic | 2improved precursor-directed production | 2genetic process strategies | 2cyclase streptomyces glaucescens | 2analysis tetracenomycin f2 | 2structural functional analysis | 2am-3672 type ii | 2hygroscopicus am-3672 type | 2strategies improved precursor-directed | 2ii polyketide cyclase | 2process strategies improved | 2type ii polyketide | 2precursor-directed production 6-deoxyerythronolide | 2levels escherichia coli | 2differences polyketide production | 2pharmaceutical-producing actinomycete strains | 2erythromycin polyketide synthase | 2production levels escherichia | 2meg m2 te | 2polyketide synthase modules | 2identification domains within
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Funding (24) [selected NIH grants to C Richard Hutchinson and the award amounts for recent years]
- RIFAMYCIN BIOSYNTHETIC ANALOGS (HUTCHINSON, CHARLES - 1996)
Grant # Award Year Award Amount, USD 1R01AI038947-01 1996 $159,309 5R01AI038947-02 1997 $148,634 5R01AI038947-03 1998 $154,999 5R01AI038947-04 1999 $161,599 2R01AI038947-05 2000 $247,675 5R01AI038947-06 2001 $233,425 5R01AI038947-07 2002 $210,083 5R01AI038947-08 2003 $233,425 Total up to 2004 $1,549,149 - FUNGAL POLYKETIDE SYNTHASES (HUTCHINSON, CHARLES - 1998)
Grant # Award Year Award Amount, USD 1R01AI043031-01 1998 $148,505 5R01AI043031-02 1999 $138,999 5R01AI043031-03 2000 $143,169 5R01AI043031-04 2001 $147,463 Total up to 2004 $578,136 - NEW KETOLIDE ANTIBACTERIAL DRUGS (HUTCHINSON, CHARLES - 2002)
Grant # Award Year Award Amount, USD 1R43AI051106-01 2002 $233,744 2R44AI051106-02 2003 $375,000 5R44AI051106-03 2004 $375,000 Total up to 2004 $983,744 - NOVEL MACROLIDES AS ANTI-INFECTIVE DRUGS (HUTCHINSON, CHARLES - 2007)
Grant # Award Year Award Amount, USD award information is not available Total up to 2004 $NA - METABOLISM OF NATURALLY OCCURRING ANTITUMOR COMPOUNDS (HUTCHINSON, CHARLES - 1976)
Grant # Award Year Award Amount, USD award information is not available Total up to 2004 $NA - METABOLISM OF NATURALLY OCCURRING ANTITUMOR COMPOUNDS (HUTCHINSON, CHARLES - 1973)
Grant # Award Year Award Amount, USD award information is not available Total up to 2004 $NA - SYNTHESIS OF ANTHRACYCLINE ANTIBIOTICS FROM TETRACYCLINE (HUTCHINSON, CHARLES - 1978)
Grant # Award Year Award Amount, USD award information is not available Total up to 2004 $NA - MEDICINAL CHEMISTRY OF ANTITUMOR IRIDOIDS (HUTCHINSON, CHARLES - 1980)
Grant # Award Year Award Amount, USD award information is not available Total up to 2004 $NA - BIOSYNTHESIS OF ANTHRACYCLINE ANTIBIOTICS (HUTCHINSON, CHARLES - 1983)
Grant # Award Year Award Amount, USD 2R01CA035381-09A1 1992 $154,441 5R01CA035381-10 1993 $200,661 5R01CA035381-11 1994 $203,485 5R01CA035381-12 1995 $214,545 5R01CA035381-13 1996 $223,794 2R01CA035381-14 1997 $226,118 5R01CA035381-15 1998 $208,400 5R01CA035381-16 1999 $214,298 5R01CA035381-17 2000 $220,116 5R01CA035381-18 2001 $226,112 Total up to 2004 $2,091,970 - DOXORUBICIN BIOSYNTHESIS AND RESISTANCE (HUTCHINSON, CHARLES - 1996)
Grant # Award Year Award Amount, USD 1R01CA064161-01A2 1996 $193,988 5R01CA064161-02 1997 $166,199 5R01CA064161-03 1998 $172,004 5R01CA064161-04 1999 $178,326 5R01CA064161-05 2000 $184,604 Total up to 2004 $895,121 - NOVEL GELDANAMYCIN ANALOGS AS ANTI-TUMOR AGENTS (HUTCHINSON, CHARLES - 2002)
Grant # Award Year Award Amount, USD 1R43CA096262-01 2002 $100,000 2R44CA096262-02 2004 $375,000 Total up to 2004 $475,000 - DM1-MONOCLONAL ANTIBODY CONJUGATES (HUTCHINSON, CHARLES - 2002)
Grant # Award Year Award Amount, USD 1R43CA097567-01 2002 $100,005 Total up to 2004 $100,005 - DISCODERMOLIDE BIOSYNTHESIS GENES (HUTCHINSON, CHARLES - 2002)
Grant # Award Year Award Amount, USD 1R43CA097889-01 2002 $100,005 Total up to 2004 $100,005 - LAULIMALIDE PRODUCTION GENES (HUTCHINSON, CHARLES - 2003)
Grant # Award Year Award Amount, USD 1R43CA099899-01 2003 $162,588 Total up to 2004 $162,588 - LEPTOMYCIN B DEVELOPMENT FOR CANCER THERAPY (HUTCHINSON, CHARLES - 2004)
Grant # Award Year Award Amount, USD 1R43CA108372-01 2004 $100,000 Total up to 2004 $100,000 - CARDIAC NEOGLYCOSIDES AS CANCER DRUGS (HUTCHINSON, CHARLES - 2007)
Grant # Award Year Award Amount, USD award information is not available Total up to 2004 $NA - THE BIOSYNTHESIS OF BREFELDING A AND JASMONIC ACID (HUTCHINSON, CHARLES - 1975)
Grant # Award Year Award Amount, USD 1F32GM020057-01 1999 $31,720 5F32GM020057-02 2000 $37,516 Total up to 2004 $69,236 - BIOGENETIC C-13 ENRICHMENT OF NATURAL PRODUCT DRUGS (HUTCHINSON, CHARLES - 1974)
Grant # Award Year Award Amount, USD award information is not available Total up to 2004 $NA - STEREOCHEMISTRY OF POLYKETIDE ANTIBIOTIC BIOSYNTHESIS (HUTCHINSON, CHARLES - 1979)
Grant # Award Year Award Amount, USD 5R01GM025799-13 1992 $144,886 Total up to 2004 $144,886 - MOLECULAR GENETICS OF ANTIBIOTIC BIOSYNTHESIS (HUTCHINSON, CHARLES - 1983)
Grant # Award Year Award Amount, USD 2R01GM031925-08 1993 $168,236 5R01GM031925-09 1994 $162,123 5R01GM031925-10 1995 $168,511 5R01GM031925-11 1996 $175,119 2R01GM031925-12 1998 $185,297 5R01GM031925-13 1999 $174,722 5R01GM031925-14 2000 $179,965 5R01GM031925-15 2001 $185,371 Total up to 2004 $1,399,344 - SMALL INSTRUMENTATION PROGRAM (HUTCHINSON, CHARLES - 1989)
Grant # Award Year Award Amount, USD award information is not available Total up to 2004 $NA - PROVIDE SMALL INSTRUMENTATION (HUTCHINSON, CHARLES - 1994)
Grant # Award Year Award Amount, USD 1S15GM052148-01 1994 $19,072 Total up to 2004 $19,072 - AUTOMATION OF NEOGLYCOSIDE SYNTHESIS (HUTCHINSON, CHARLES - 2008)
Grant # Award Year Award Amount, USD award information is not available Total up to 2004 $NA - MIDFIELD NMR SPECTROMETER (HUTCHINSON, CHARLES - 1987)
Grant # Award Year Award Amount, USD award information is not available Total up to 2004 $NA
C Richard Hutchinson Articles (5) [selected PubMed articles for the year 2004 with the links to a full text at PubMed]
Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli. (2004) >>
Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, California 94545, USA.
4McDaniel, Robert, 1Murli, Sumati, 5Hutchinson, C Richard, .Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase. (2004) >>
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
12Rayment, Ivan, 3Thompson, Thomas B, 19Watanabe, Kenji, 5Hutchinson, C Richard, .Isolation and characterization of novel geldanamycin analogues. (2004) >>
Kosan Biosciences, Inc., 3832 Bay Center Place Hayward, CA 94545 USA.
3Tian, Zong-Qiang, 3Regentin, Rika, 3Myles, David C, 5Hutchinson, C Richard, 6Licari, Peter, 2Starks, Courtney M, 4Hu, Zhihao, 7Ma, Wei, 2Liu, Yaoquan.Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. (2004) >>
Department of Chemical Engineering, MC 5025, Stanford University, CA 94305, USA.
5Hutchinson, C Richard, 3Kao, Camilla M, 2Huang, Jianqiang, .Combining classical, genetic, and process strategies for improved precursor-directed production of 6-deoxyerythronolide B analogues. (2004) >>
Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, California 94545, USA.
, , 5Hutchinson, C Richard, 6Licari, Peter, , , , 4Hu, Zhihao.
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