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5Ulrich Bierbach

 

Summary for 2004 [at-glance overview of Ulrich Bierbach work for the selected year as suggested by data mining algorithms]

This is an Authoratory overview of author Ulrich Bierbach. According to available data, in 2004 Ulrich Bierbach published at least 5 articles. This work was completed in collaboration with several authors including Baruah, Hemanta and Day, Cynthia S. There is at least one grant awarded to support this work. All time total of the grant awards on file exceeds $896,449.

Ulrich Bierbach has rank 6 when compared to all other authors using the keyword Intercalating Agents. Analysis of the article abstracts and the titles suggests that Ulrich Bierbach professional interests are focused around "thiourea nonleaving group", "effect thiourea nonleaving" and "platinum-acridinylthiourea conjugates effect". These might also be referred to as "platinum-acridinylthiourea conjugates", "structure-activity relationships" or "nonleaving group". Statistical analysis shows that Ulrich Bierbach's writing is likely to contains terms "dna", "binding", "cisplatin", "conjugates", "platinum-acridinylthiourea" and "thiourea".

The majority of Ulrich Bierbach articles are affiliated with Department of Chemistry, Wake Forest University, P.O. PO Box 7486 Reynolda Station, Winston-Salem, North Carolina NC 27109, USA. Sadly, no email addresses were found for any of the affiliations.

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Alternative names (1) [other authors with names similar to Ulrich Bierbach]

Year 2004 Charts [Ulrich Bierbach frequent coauthors and the most common unique vocabulary terms for the selected year]

  • Ulrich Bierbach - Coauthors & Social Network in 2004Ulrich Bierbach - Unique Vocabulary, Keywords and Interests in 2004

Historical Performance Charts [graphical overview of Ulrich Bierbach publication and funding history for the range of years]

  • Ulrich Bierbach - Publications and Funding History in 2004

Ulrich Bierbach Coauthors (4) [all coauthors with the number of joint publications]

3

3Baruah, Hemanta

2

3Day, Cynthia S

2

3Wright, Marcus W

1

5Berners-Price, Susan J

 

Other [context-specific ads]

Affiliations (2) [condensed summary of the Ulrich Bierbach affiliations, the leading number and the color conveys importance]

  • 4Department of Chemistry, Wake Forest University, P.O. PO Box 7486 Reynolda Station, Winston-Salem, North Carolina NC 27109, USA.
    1Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109-7486, USA.

Key Opinion Leader In [Ulrich Bierbach is considered a key opinion leader in any keyword where the rank of 5 is achieved, the leading number before the keyword shows the author's rank as compared to all other authors]

  • 6Intercalating Agents | 13Thiourea | 25Organoplatinum Compounds | 716Antineoplastic Agents | 816Binding Sites

Keywords (32) [keywords assigned to Ulrich Bierbach articles by PubMed, the leading number and the color conveys importance]

  • 3Organoplatinum Compounds | 3Thiourea | 3Binding Sites | 3Antineoplastic Agents | 3Intercalating Agents | 2Urea | 2DNA | 2Humans | 2Cisplatin | 2Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2DNA Adducts | 2Models, Molecular | 1Cross-Linking Reagents | 1Base Sequence | 1Gene Expression Regulation, Neoplastic | 1RNA | 1Cell Line, Tumor | 1Platinum | 1Crystallography, X-Ray | 1Protein Binding | 1DNA Damage | 1Half-Life | 1Molecular Conformation | 1Nucleic Acid Heteroduplexes | 1Nucleosides | 1Time Factors | 1Circular Dichroism | 1Molecular Sequence Data | 1Adenine | 1Nuclear Magnetic Resonance, Biomolecular | 1Drug Stability | 1Acridines

Ulrich Bierbach Unique Vocabulary (96) [single words, word pairs and phrases obtained by analysis of abstracts and titles, the leading number and the color conveys importance; Ulrich Bierbach might be a good expert witness on these terms]

  • 15dna | 11binding | 9cisplatin | 8conjugates | 7platinum-acridinylthiourea | 7thiourea | 6agents | 6major | 5modified | 5damage | 5using | 5agent | 5drug | 5sites | 5sequence | 5derivatives | 4group | 4adduct | 4nucleobase | 4platinum | 4groove | 4molecular | 3structure-activity | 3nonleaving | 3structural | 3cytotoxicity | 3rate | 3relationships | 3guanine | 3class | 3nmr | 3tetraalkylated
  • 3platinum-acridinylthiourea conjugates | 3structure-activity relationships | 3nonleaving group | 3thiourea nonleaving | 3cisplatin derivatives | 3dna binding | 3platinum-intercalator conjugates | 2rate binding | 2drug stability | 2major groove | 2affinity vitro | 2biological consequences | 2conjugates effect | 2site-specifically modified | 2coordinative-intercalative dna | 2monoadduct platinum-acridinylthiourea | 2relationships platinum-acridinylthiourea | 2modeling coordinative-intercalative | 2dna monoadduct | 2modified dodecamer | 2conjugates class | 2biophysical characterization | 2guanine bases | 2nmr spectroscopy | 2characterization molecular | 2dna adduct | 2effect thiourea | 2agent site-specifically | 2vitro cytotoxicity | 2stability nucleobase | 2a2780 cp | 2group drug
  • 3thiourea nonleaving group | 2effect thiourea nonleaving | 2platinum-acridinylthiourea conjugates effect | 2site-specifically modified dodecamer | 2nucleobase affinity vitro | 2structure-activity relationships platinum-acridinylthiourea | 2dna monoadduct platinum-acridinylthiourea | 2conjugates effect thiourea | 2modeling coordinative-intercalative dna | 2platinum-acridinylthiourea agent site-specifically | 2molecular modeling coordinative-intercalative | 2affinity vitro cytotoxicity | 2characterization molecular modeling | 2group drug stability | 2biophysical characterization molecular | 2stability nucleobase affinity | 2agent site-specifically modified | 2coordinative-intercalative dna monoadduct | 2drug stability nucleobase | 2relationships platinum-acridinylthiourea conjugates | 2monoadduct platinum-acridinylthiourea agent | 2nonleaving group drug | 2adenine binding complexes | 2dna damage profile | 2leads dna damage | 2derivatives adenine binding | 2complementary anticancer drug | 2recognition platinum-acridinylthiourea conjugate | 2conjugate leads dna | 2cisplatin derivatives adenine | 2anticancer drug cisplatin | 2platinum-acridinylthiourea conjugate leads

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Funding (1) [selected NIH grants to Ulrich Bierbach and the award amounts for recent years]

  • NOVEL DNA-METALATING HYBRID ANTICANCER AGENTS (BIERBACH, ULRICH - 2003)
    Grant #Award YearAward Amount, USD
    1R01CA101880-012003$223,716
    5R01CA101880-022004$224,639
    Total up to 2004$448,355

Ulrich Bierbach Articles (5) [selected PubMed articles for the year 2004 with the links to a full text at PubMed]

  • Unique base-step recognition by a platinum-acridinylthiourea conjugate leads to a DNA damage profile complementary to that of the anticancer drug cisplatin. (2004) >>

    Department of Chemistry, Wake Forest University, P.O. Box 7486 Reynolda Station, Winston-Salem, North Carolina 27109, USA.

    1Alexander, Rebecca W, 5Bierbach, Ulrich, 1Budiman, Michael E.

  • Structure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity. (2004) >>

    Department of Chemistry, Wake Forest University, P.O. Box 7486 Reynolda Station, Winston-Salem, NC 27109, USA.

    3Wright, Marcus W, 1Mounce, Amanda M, 3Day, Cynthia S, 2Hess, Suzanne M, 1Farmer, Michael C, 2Barry, Colin G, 1Springer, Beth-Erin, 5Bierbach, Ulrich, 1Ackley, Margaret C, 5Berners-Price, Susan J.

  • Metal-intercalator-mediated self-association and one-dimensional aggregation in the structure of the excised major DNA adduct of a platinum-acridine agent. (2004) >>

    Department of Chemistry, Wake Forest University, P.O. Box 7486, Reynolda Station, Winston-Salem, North Carolina 27109, USA.

    3Wright, Marcus W, 3Day, Cynthia S, 3Baruah, Hemanta, 5Bierbach, Ulrich.

  • Biophysical characterization and molecular modeling of the coordinative-intercalative DNA monoadduct of a platinum-acridinylthiourea agent in a site-specifically modified dodecamer. (2004) >>

    Department of Chemistry, Wake Forest University, PO Box 7486 Reynolda Station, Winston-Salem, NC 27109, USA.

    3Baruah, Hemanta, 5Bierbach, Ulrich.

  • Platinum-intercalator conjugates: from DNA-targeted cisplatin derivatives to adenine binding complexes as potential modulators of gene regulation. (2004) >>

    Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109-7486, USA.

    2Barry, Colin G, 3Baruah, Hemanta, 5Bierbach, Ulrich.

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