₇₁Shizuo Akira

Shizuo Akira Articles (71) [selected PubMed articles for the year 2007 with the links to a full text at PubMed]

• Too much data, only first 100 publications and/or coauthors will be displayed. Unabridged data can only be viewed as XML or CSV documents.

• IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{epsilon}RI signals. (2007) >>

  L-235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.

  ₂Kajiwara, Naoki, ₃Ho, Lien H, ₅Okayama, Yoshimichi, ₁₀Galli, Stephen J, ₅Iikura, Motoyasu, ₁₀Nakae, Susumu, ₁₈Saito, Hirohisa, ₇Suto, Hajime, ₇₁Akira, Shizuo, ₃Oboki, Keisuke, ₃Ohno, Tatsukuni.

• IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. (2007) >>

  Laboratory of Molecular Immunology and Embryology, University of Orleans and CNRS, Orleans, France. INSERM U620, Université de Rennes 1, Rennes, France. Key-Obs SA, Orleans, France. Osaka University, Suita, Osaka, Japan.

  ₂Guenon, Isabelle, ₁₆Ryffel, Bernhard, ₂Charron, Sabine, ₈Quesniaux, Valerie F J, ₁Mary, Caroline, ₄Lagente, Vincent, ₄Schnyder, Bruno, ₄Couillin, Isabelle, ₂Gasse, Pamela, ₇₁Akira, Shizuo, ₄Schnyder-Candrian, Silvia, ₃Noulin, Nicolas.

• Recognition of viruses by innate immunity. (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, ERATO, Japan Science and Technology Agency, Osaka, Japan.

  ₁₄Takeuchi, Osamu, ₇₁Akira, Shizuo.

• Deletion of TLR5 results in spontaneous colitis in mice. (2007) >>

  Department of Pathology, Emory University, Atlanta, Georgia 30322, USA.

  ₅Neish, Andrew S, ₂Taylor, Rebekah T, ₇Gewirtz, Andrew T, ₁Aitken, Jesse D, ₁₀Williams, Ifor R, ₁₄Sitaraman, Shanthi V, ₂Kumar, Amrita, ₁₈Uematsu, Satoshi, ₂Vijay-Kumar, Matam, ₇₁Akira, Shizuo, ₁Sanders, Catherine J.

• The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. (2007) >>

  Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, the University of Miami, Miller School of Medicine, 1550 NW 10 Avenue, Miami, FL 33136, USA.

  ₄Harhaj, Nicole S, ₅Harhaj, Edward W, ₂Shembade, Noula, ₇₁Akira, Shizuo, ₃₈Yamamoto, Masahiro.

• Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. (2007) >>

  Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan.

  ₅Ohkawa, Kazuyoshi, ₆Tatsumi, Tomohide, ₄Sakamori, Ryotaro, ₁Ohnishi, Chihiro, ₇Takehara, Tetsuo, ₇₁Akira, Shizuo, ₂₀Hayashi, Norio, ₄Takeda, Kiyoshi.

• Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responses. (2007) >>

  Division of Immunology, Paul-Ehrlich-Institut, D-63225, Langen, Germany.

  ₄Waibler, Zoe, ₁Ludwig, Holger, ₁₀Sutter, Gerd, ₉Kalinke, Ulrich, ₁Anzaghe, Martina, ₁₃Weiss, Siegfried, ₇₁Akira, Shizuo.

• Signaling to NF-kappaB by Toll-like receptors. (2007) >>

  Department of Host Defense and Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

  ₁₂Kawai, Taro, ₇₁Akira, Shizuo.

• Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. (2007) >>

  Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

  ₄Berrington, William R, ₆Smith, Kelly D, ₄Skerrett, Shawn J, ₁₀Aderem, Alan, ₁Smith, Ian A, ₅Hawn, Thomas R, ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo.

• FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction. (2007) >>

  Department of Medical Biophysics, British Columbia Cancer Research Centre, University of British Columbia , 675 West 10th Ave., Vancouver, BC V5Z 1L3, Canada.

  ₂Dauphinee, Shauna M, ₄Karsan, Aly, ₅Thomas, James A, ₇₁Akira, Shizuo, ₂Zhande, Rachel, ₃₈Yamamoto, Masahiro.

• Calcineurin negatively regulates TLR-mediated activation pathways. (2007) >>

  Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.

  ₁₆Han, Jiahuai, ₁Jones, Patricia P, ₂Suzuki, Shinobu, ₅Yeh, Wen-Chen, ₅Kang, Young Jun, ₁Kusler, Brenda, ₈Hughes, Michael, ₇₁Akira, Shizuo, ₃Suzuki, Nobutaka, ₄Otsuka, Motoyuki.

• Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination. (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka, Japan.

  ₄Coban, Cevayir, ₁₂Kawai, Taro, ₃Tanimoto, Takeshi, ₈Ishii, Ken J, ₁Koyama, Shohei, ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo, ₄Kumar, Himanshu.

• The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan.

  ₃Omori, Hiroko, ₂₇Tanaka, Takashi, ₁Yamakami, Megumi, ₁₁Yoshimori, Tamotsu, ₄Matsumoto, Makoto, ₁₈Uematsu, Satoshi, ₄Kaisho, Tsuneyasu, ₇₁Akira, Shizuo, ₃₈Yamamoto, Masahiro.

• Genetic analysis of resistance to viral infection. (2007) >>

  Department of Genetics, The Scripps Research Institute, IMM-3-1, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.

  ₃Hoffmann, Jules A, ₁₅Beutler, Bruce, ₃Crozat, Karine, ₁₄Takeuchi, Osamu, ₁Eidenschenk, Céline, ₆Imler, Jean-Luc, ₇₁Akira, Shizuo.

• Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif. (2007) >>

  Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

  ₁Cook, Pamela, ₁Stevenson, Catherine, ₉Fitzgerald, Katherine A, ₅Bryant, Clare E, ₇Maskell, Duncan J, ₇₁Akira, Shizuo, ₁Tötemeyer, Sabine, ₃₈Yamamoto, Masahiro.

• Nitrogen dioxide promotes allergic sensitization to inhaled antigen. (2007) >>

  Vermont Lung Center, University of Vermont, Burlington, VT 05405, USA.

  ₂Mayette, Jana, ₄Whittaker, Laurie A, ₂Bevelander, Mieke, ₄Hemenway, David, ₃Jones, Christine C, ₂Paveglio, Sara A, ₁₈Uematsu, Satoshi, ₄Poynter, Matthew E, ₇₁Akira, Shizuo, ₂Robbins, Justin.

• MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus. (2007) >>

  Institutes of Experimental Immunology, Neuropathology and Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland.

  ₃Bergthaler, Andreas, ₉Heikenwalder, Mathias, ₄Honda, Kenya, ₁Stecher, Barbara, ₈Hengartner, Hans, ₇Odermatt, Bernhard, ₇Lang, Karl S, ₉Lang, Philipp A, ₇₁Akira, Shizuo, ₉Zinkernagel, Rolf M, ₅Recher, Mike, ₁Navarini, Alexander A.

• TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells. (2007) >>

  Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

  ₄McMillan, Tracy R, ₆Moore, Thomas A, ₂Newstead, Michael W, ₁Bhan, Urvashi, ₁Osterholzer, John J, ₇Standiford, Theodore J, ₇₁Akira, Shizuo, ₁₄Lukacs, Nicholas W, ₁₅Krieg, Arthur M, ₂Zeng, Xianying.

• Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance. (2007) >>

  Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, Immunos.

  ₂Bist, Pradeep, ₃Biswas, Subhra K, ₁Dhillon, Manprit Kaur, ₅del Fresno, Carlos, ₅López-Collazo, Eduardo, ₇₁Akira, Shizuo, ₇Tergaonkar, Vinay, ₃₈Yamamoto, Masahiro, ₁Kajiji, Tasneem.

• Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines. (2007) >>

  Department of Molecular Virology, Graduate School of Medicine, Osaka University, Osaka, Japan.

  ₁₃Matsuura, Yoshiharu, ₁₂Kawai, Taro, ₁Taguwa, Shuhei, ₁Wen, Xiaoyu, ₇₁Akira, Shizuo, ₂Hamamoto, Itsuki, ₆Kanto, Tatsuya, ₉Moriishi, Kohji, ₁Kaname, Yuuki, ₁₄Takeuchi, Osamu, ₃Abe, Takayuki, ₃Tsuda, Yoshimi, ₂₀Hayashi, Norio.

• Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. (2007) >>

  Department of Host Defense and Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.

  ₁₃Matsuura, Yoshiharu, ₇Satoh, Takashi, ₁₂Kawai, Taro, ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo, ₄Kumar, Himanshu, ₃₈Yamamoto, Masahiro, ₅Sato, Shintaro, ₃Saitoh, Tatsuya, ₁Okamoto, Toru, ₁₄Takeuchi, Osamu, ₈Ishii, Ken J, ₄Takeda, Kiyoshi.

• Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes. (2007) >>

  Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

  ₁Lee, Hyun Ah, ₃Youn, Jeehee, ₄Kim, Hun Sik, ₁Jang, Eunkyeong, ₃Kim, Sunshin, ₂Han, Myoung Sook, ₁Kim, Eunshil, ₇₁Akira, Shizuo, ₂Chung, Kun Wook, ₁Kim, Myoung Joo, ₉Lee, Myung-Shik.

• Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. (2007) >>

  Department of Immunology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.

  ₁₀Iwata, Makoto, ₄Matsushita, Masayuki, ₂Abe, Yukiko, ₂Takeuchi, Hajime, ₇₁Akira, Shizuo, ₅Ohteki, Toshiaki, ₉Shiohara, Tetsuo, ₅Ishikawa, Hiromichi, ₁Tezuka, Hiroyuki.

• [Toll-like receptor and innate immunity] (2007) >>

  Department of Host Defense Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.

  ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo.

• Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

  ₁Kumagai, Yutaro, ₂₁Aozasa, Katsuyuki, ₁₂Kawai, Taro, ₁₄Takeuchi, Osamu, ₁₁Morii, Eiichi, ₅Matsui, Kosuke, ₇₁Akira, Shizuo, ₁₀Kato, Hiroki, ₄Kumar, Himanshu.

• The Atg5 Atg12 conjugate associates with innate antiviral immune responses. (2007) >>

  Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.

  ₃Sawano, Asako, ₂Kobiyama, Kouji, ₃Jounai, Nao, ₁₂Kawai, Taro, ₁₇Miyawaki, Atsushi, ₇Takeshita, Fumihiko, ₈Ishii, Ken J, ₇Xin, Ke-Qin, ₂₀Suzuki, Koichi, ₇₁Akira, Shizuo, ₁₂Okuda, Kenji.

• Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. (2007) >>

  Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, CA 94305, USA.

  ₄Li, Jiali, ₃Varghese, Bindu, ₈Levy, Ronald, ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo, ₁Czerwinski, Debra K, ₁₅Krieg, Arthur M, ₁Song, Wenru.

• Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. (2007) >>

  Institute of Biochemistry II, Goethe University Medical School, Frankfurt, Germany.

  ₈Hofmann, Kay, ₁Hecker, Christina Maria, ₈Dikic, Ivan, ₂Rogov, Vladimir, ₁Nordmeier, Rolf Dietrich, ₁Rozenknop, Alexis, ₂Ikeda, Fumiyo, ₁₀Dötsch, Volker, ₇₁Akira, Shizuo.

• Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population. (2007) >>

  Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.

  ₃Yasutomo, Koji, ₂Kishihara, Kenji, ₁Maekawa, Yoichi, ₁₀Kagami, Shoji, ₂Kimoto, Yasutaka, ₁Fujii, Mutsuko, ₂Tsukumo, Shin-ichi, ₂Horiuchi, Takahiko, ₁Tao, Kayoko, ₇₁Akira, Shizuo, ₄Hisaeda, Hajime.

• Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. (2007) >>

  Division of Nephrology, Pennsylvania State College of Medicine, 500 Univ. Dr., Hershey, PA 17033, USA.

  ₂Ramesh, Ganesan, ₂Reeves, W Brian, ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo, ₁Zhang, Binzhi.

• The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. (2007) >>

  Department of Microbiology and Immunology, University of Maryland-Baltimore, Baltimore, MD 21201, USA.

  ₁₄Vogel, Stefanie N, ₁₂Kawai, Taro, ₁Roberts, Zachary J, ₁Van Echo, David, ₂Goutagny, Nadège, ₇₁Akira, Shizuo, ₄Kumar, Himanshu, ₈Young, Howard A, ₂Savan, Ram, ₁Perera, Pin-Yu, ₅Ching, Lai-Ming, ₉Fitzgerald, Katherine A, ₁₀Kato, Hiroki.

• A polysaccharide carrier to effectively deliver native phosphodiester CpG DNA to antigen-presenting cells. (2007) >>

  Department of Chemical Processes & Environments, The University of Kitakyushu, 1-1, Hibikino, Wakamatu-ku, Kitakyushu, Fukuoka 808-0135, Japan.

  ₆Sakurai, Kazuo, ₂Minari, Jusaku, ₄Coban, Cevayir, ₂Torii, Yuichi, ₃Takeda, Yoichi, ₈Ishii, Ken J, ₇₁Akira, Shizuo, ₆Shimada, Naohiko, ₁₄Shinkai, Seiji, ₃Anada, Takahisa, ₁Mizu, Masami.

• Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. (2007) >>

  Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Room S2-109, Worcester, Massachusetts 01655, USA.

  ₅Golenbock, Douglas, ₅Chen, Chun-Jen, ₆Reed, George, ₆Rock, Kenneth L, ₇₁Akira, Shizuo, ₁Kono, Hajime.

• Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. (2007) >>

  Program in Immunology and Department of Pathology, Sackler School of Graduate Biomedical Sciences and Tufts University School of Medicine, Boston, MA 02111, USA.

  ₆Calame, Kathryn, ₁Imanishi-Kari, Thereza, ₁₅Beutler, Bruce, ₄Selsing, Erik, ₇₁Akira, Shizuo, ₁Han, Jin-Hwan.

• Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine. (2007) >>

  Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.

  ₂Kobiyama, Kouji, ₄Matsuda, Tomoko, ₆Sasaki, Shin, ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo, ₁₃Matsumoto, Tetsuya, ₃Jounai, Nao, ₇Takeshita, Fumihiko, ₅Klinman, Dennis M, ₈Ishii, Ken J, ₁₃Yoshida, Atsushi, ₇Xin, Ke-Qin, ₁₂Okuda, Kenji, ₆Saha, Sukumar.

• Toll or toll-free adjuvant path toward the optimal vaccine development. (2007) >>

  Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), Osaka University, Suita, Osaka 565-0871, Japan.

  ₈Ishii, Ken J, ₇₁Akira, Shizuo.

• Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. (2007) >>

  Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

  ₂Rifkin, Ian R, ₁Richez, Christophe, ₁Maciaszek, Joseph W, ₈Agrawal, Neerja, ₂Yasuda, Kei, ₇Marshak-Rothstein, Ann, ₇₁Akira, Shizuo.

• SnapShot: Pattern-recognition receptors. (2007) >>

  Research Institute for Microbial Diseases, Osaka University, Japan.

  ₁₂Kawai, Taro, ₇₁Akira, Shizuo.

• Manipulation of host innate immune responses by the malaria parasite. (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita City, Osaka 565-0871, Japan.

  ₈Horii, Toshihiro, ₄Coban, Cevayir, ₈Ishii, Ken J, ₇₁Akira, Shizuo.

• ER stress triggers apoptosis by activating BH3-only protein Bim. (2007) >>

  The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

  ₁Gotoh, Tomomi, ₁₉Strasser, Andreas, ₃Michalak, Ewa M, ₄Kelly, Priscilla N, ₁O'Reilly, Lorraine A, ₇₁Akira, Shizuo, ₁Motoyama, Noburo, ₁Hughes, Peter D, ₃Gunn, Priscilla, ₂McKimm-Breschkin, Jennifer, ₇Bouillet, Philippe, ₄Lee, Lily, ₄Puthalakath, Hamsa, ₆Huntington, Nicholas D.

• Cutting edge: TLR2 directly triggers Th1 effector functions. (2007) >>

  Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan.

  ₂Imanishi, Takayuki, ₂Suzuki, Shinobu, ₆Hara, Hiromitsu, ₇₁Akira, Shizuo, ₁₃Saito, Takashi, ₃Suzuki, Nobutaka.

• [Pathogen recognition by innate immunity] (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan.

  ₁₄Takeuchi, Osamu, ₇₁Akira, Shizuo.

• Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2a. (2007) >>

  Mucosal Immunology Section, International Vaccine Institute, Seoul National University Research Park, Kwanak-Gu, Seoul 151-818, Republic of Korea.

  ₄Czerkinsky, Cecil, ₂Carbis, Rodney, ₂Shim, Doo-Hee, ₃Chang, Sun-Young, ₁Jang, Hyun, ₉Kweon, Mi-Na, ₁₈Uematsu, Satoshi, ₂Park, Sung-moo, ₇₁Akira, Shizuo.

• A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. (2007) >>

  Program in Molecular and Cellular Neuroscience, Dental Research Institute, BK21, and Department of Oral Physiology, School of Dentistry, Seoul National University, Seoul 110-749, Korea.

  ₂Kim, Myung Ah, ₄Oh, Seog Bae, ₃Lee, Soojin, ₁Kim, DongHoon, ₇₁Akira, Shizuo, ₃Kim, Joong Soo, ₃Choi, Se-Young, ₉Jo, Eun-Kyeong, ₆Lee, Sung Joong, ₂Na, Heung Sik, ₁₀Kim, Mi Sun, ₂Park, Kyungpyo, ₃Cho, Ik-hyun.

• Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori. (2007) >>

  School of Medicine, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0640, USA.

  ₅Sabet, Mojgan, ₂Guiney, Donald G, ₁Cole, Sheri P, ₁Obonyo, Marygorret, ₂Ebmeyer, Joerg, ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo.

• Toll-like receptor 2 does not contribute to host response during postinfluenza pneumococcal pneumonia. (2007) >>

  Center for Infection and Immunity Amsterdam (CINIMA), Laboratory of Experimental Immunology, Department of Pulmonology, University of Amsterdam, The Netherlands.

  ₆Dessing, Mark C, ₃van der Sluijs, Koenraad F, ₂₉van der Poll, Tom, ₁₇Florquin, Sandrine, ₇₁Akira, Shizuo.

• Toll-like receptors. (2007) >>

  Osaka University, Osaka, Japan.

  ₇₁Akira, Shizuo, ₄Takeda, Kiyoshi.

• Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.

  ₁₄Takeuchi, Osamu, ₁Kawagoe, Tatsukata, ₅Matsui, Kosuke, ₁₈Uematsu, Satoshi, ₆Jung, Andreas, ₇₁Akira, Shizuo, ₁₀Kato, Hiroki, ₅Sato, Shintaro, ₃₈Yamamoto, Masahiro.

• Toll-like receptors and Type I interferons. (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and ERATO, Japan Science and Technology Corporation, 3-1 Yamada-oka, Suita Osaka 565-0871, Japan.

  ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo.

• Signaling pathways activated by microorganisms. (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, ERATO, Japan Science and Technology Agency, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

  ₁₄Takeuchi, Osamu, ₇₁Akira, Shizuo.

• Interleukin-18 regulates pathological intraocular neovascularization. (2007) >>

  Ophthalmology, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.

  ₂Yoshimura, Takeru, ₉Ikeda, Yasuhiro, ₆Sonoda, Koh-Hei, ₂Hijioka, Kuniaki, ₉Hata, Yasuaki, ₁Tsutsumi-Miyahara, Chikako, ₁₅Ishibashi, Tatsuro, ₇₁Akira, Shizuo, ₃Qiao, Hong, ₁Jo, Young-Joon, ₃Sassa, Yukio.

• TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. (2007) >>

  Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA.

  ₉Chen, Zhijian, ₂Sun, Lijun, ₁₄Takeuchi, Osamu, ₃Shin, Young C, ₈Urano, Tomohiko, ₉Jung, Jae U, ₂₅Inoue, Satoshi, ₇₁Akira, Shizuo, ₄Liang, Chengyu, ₁Gack, Michaela U, ₁Joo, Chul-Hyun.

• Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection. (2007) >>

  Institute for Systems Biology, Seattle, WA 98103, USA.

  ₂Nachman, Alex, ₆Smith, Kelly D, ₃Andersen-Nissen, Erica, ₁₀Aderem, Alan, ₁Lampano, Aaron E, ₅Hawn, Thomas R, ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo.

• A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-beta in the host response to Pseudomonas aeruginosa lung infection in mice. (2007) >>

  Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.

  ₃Lin, Tong-Jun, ₁Power, Melanie R, ₇₉Li, Bo, ₇₁Akira, Shizuo, ₃₈Yamamoto, Masahiro.

• Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo. (2007) >>

  Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstrasse 30, 81675 München, Germany.

  ₄Huster, Katharina M, ₁₅Bauer, Stefan, ₅Heit, Antje, ₇₁Akira, Shizuo, ₁₃Busch, Dirk H, ₂Koffler, Martina, ₂Hamm, Svetlana, ₁Wagner, Herrmann.

• Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways. (2007) >>

  Department of Pediatrics, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan.

  ₃Tsutsui, Hiroko, ₁Sawaki, Junko, ₂Yasuda, Koubun, ₂Hayashi, Nobuki, ₆Nakanishi, Kenji, ₂Tanizawa, Takakuni, ₇₁Akira, Shizuo.

• Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification. (2007) >>

  Department of Immunology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

  ₁₀Li, Xiaoxia, ₂Qian, Wen, ₂Qin, Jinzhong, ₃Jiang, Zhengfan, ₇₁Akira, Shizuo, ₃Yao, Jianhong, ₃Gulen, Muhammet Fatih, ₅Sato, Shintaro, ₄₉Lu, Yi, ₁₃Xiao, Hui, ₄Sizemore, Nywana, ₂Kim, Tae Whan, ₂DiDonato, Joseph, ₁₄Su, Bing, ₂Qian, Youcun.

• Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. (2007) >>

  Swedish Institute for Infectious Disease Control and Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels väg 18, SE-171 82 Solna, Sweden.

  ₄Wartha, Florian, ₂Albiger, Barbara, ₂Sandgren, Andreas, ₅Henriques-Normark, Birgitta, ₁Katsuragi, Hiroaki, ₁Dahlberg, Sofia, ₃Beiter, Katharina, ₇₁Akira, Shizuo, ₄Normark, Staffan.

• MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. (2007) >>

  Department of Microbiology and Immunology and Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

  ₃Lien, Egil, ₂Alugupalli, Kishore R, ₇₁Akira, Shizuo, ₃Leong, John M.

• Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia. (2007) >>

  Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street Neustadt D-403, Denver, CO 80206, USA.

  ₁Young, Scott K, ₂Jeyaseelan, Samithamby, ₆Liu, Yuhong, ₇₁Akira, Shizuo, ₃Fessler, Michael B, ₂Worthen, G Scott, ₂Malcolm, Kenneth C, ₃₈Yamamoto, Masahiro.

• Viral infections activate types I and III interferon genes through a common mechanism. (2007) >>

  Laboratory of Molecular Genetics, Institute for Virus Research and Graduate School of Biostudies, Kyoto University, Kyoto 606-8507, Japan.

  ₁Takemura, Azumi, ₄Taniguchi, Tadatsugu, ₂Onoguchi, Kazuhide, ₇₁Akira, Shizuo, ₁₃Fujita, Takashi, ₇Yoneyama, Mitsutoshi, ₆Namiki, Hideo.

• Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. (2007) >>

  Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany.

  ₆Ludewig, Burkhard, ₂Züst, Roland, ₃Thiel, Volker, ₈Weber, Friedemann, ₇Lang, Karl S, ₇₁Akira, Shizuo, ₂Spiegel, Martin, ₂Cervantes-Barragán, Luisa.

• Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2. (2007) >>

  Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301-747, Seoul, Korea.

  ₉Jo, Eun-Kyeong, ₅Song, Chang-Hwa, ₁₀Tanaka, Sakae, ₆Lee, Sung Joong, ₁Paik, Tae-Hyun, ₅Lee, Ji-Sook, ₆Yang, Chul-Su, ₇₁Akira, Shizuo, ₂Hur, Gang Min.

• Antiviral signaling through pattern recognition receptors. (2007) >>

  Department of Host Defense, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

  ₁₂Kawai, Taro, ₇₁Akira, Shizuo.

• TLR signaling. (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Yamada-oka, Suita, Osaka, Japan.

  ₁₂Kawai, Taro, ₇₁Akira, Shizuo.

• TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses. (2007) >>

  Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zürich-Schlieren, Switzerland.

  ₁Shamshiev, Abdijapar, ₁Donda, Alena, ₁₈Uematsu, Satoshi, ₈Kopf, Manfred, ₇₁Akira, Shizuo, ₅Marsland, Benjamin J, ₁Heer, Alex K.

• NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. (2007) >>

  School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland.

  ₅Golenbock, Douglas, ₁Miggin, Sinead M, ₃Dunne, Aisling, ₁Moynagh, Paul, ₁Pålsson-McDermott, Eva, ₁Jefferies, Caroline, ₁₅O'Neill, Luke A J, ₇₁Akira, Shizuo, ₃₈Yamamoto, Masahiro, ₁Rothwell, Nancy, ₃Pinteaux, Emmanuel, ₉Fitzgerald, Katherine A, ₁Banahan, Kathy, ₃Murphy, Caroline.

• Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. (2007) >>

  Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

  ₄Saijo, Shinobu, ₇Sudo, Katsuko, ₉Kawakami, Kazuyoshi, ₃Kotaki, Hayato, ₇₁Akira, Shizuo, ₁₅Ohno, Naohito, ₁Chung, Soo-Hyun, ₁₂Adachi, Yoshiyuki, ₃₄Iwakura, Yoichiro, ₅Kinjo, Takeshi, ₅Nakamura, Kiwamu, ₁₀Furuta, Takahisa, ₃Seki, Keisuke, ₁Fujikado, Noriyuki.

• Pathological role of Toll-like receptor signaling in cerebral malaria. (2007) >>

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.

  ₈Horii, Toshihiro, ₄Coban, Cevayir, ₁₂Kawai, Taro, ₄Arisue, Nobuko, ₈Ishii, Ken J, ₁₄Takeuchi, Osamu, ₁₈Uematsu, Satoshi, ₇₁Akira, Shizuo, ₅Sato, Shintaro, ₄Hisaeda, Hajime, ₃₈Yamamoto, Masahiro.

• Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury. (2007) >>

  Winters Center for Heart Failure Research, 1709 Dryden-BCM, 620-Rm 9.83, Houston, TX 77030, USA.

  ₂Vallejo, Jesus G, ₁₁Mann, Douglas L, ₁Tacheuchi, Osamu, ₁₁Huang, Chien-Hua, ₄Sakata, Yasushi, ₁₄Tracey, Kevin J, ₂Baker, J Scott, ₇₁Akira, Shizuo, ₂Dong, Jian-Wen.

• Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. (2007) >>

  Department of Microbiology, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75235-9048, USA.

  ₁Sinha, Sangita C, ₆Owen, David, ₂Hirai, Reiko, ₃Loo, Yueh-Ming, ₁₀Gale, Michael, ₃Johnson, Cynthia L, ₂₁Saito, Takeshi, ₇₁Akira, Shizuo, ₁₃Fujita, Takashi.