yarmoluk
Joined: 27 Feb 2008
Posts: 22
Location: Ukraine
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 Posted: Thu Mar 06, 2008 2:16 pm Post subject: new Death-Associated Protein Kinase 2 (DAPK-2) inhibitors |
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OTAVA offers new Death-Associated Protein Kinase 2 (DAPK-2) focused Library.
The library was prepared on the base Stock Collections (about 500,000 compounds total) using receptor-based virtual screening.
Design of the focused libraries consists in Lipinsky/Veber rules filtering and flexible docking in a protein target of certain enzyme family. Further computational analysis for the presence of critical receptor-ligand hydrogen bond(s) and docking score refinement makes our focused libraries good starting point for drug discovery purposes.
The detection of H-bonds between ligand and key DAPK-2 residues (Val96, Lys42, Asp161) was used for the library preparation.
About Otava
Otava supplies Receptor Based and Target Focused compound libraries, custom synthesis, fine chemicals, ProHit compounds, protein kinase inhibitors, combinatorial chemistry templates and building blocks, fluorescent cyanine dyes, Noteworthy Compounds. They offer design and development of fluorescent probes, kits and reagents.
Company contact information:
OTAVA
P.O. Box 88
Kyiv 187, 03187
Ukraine
E-mails:
OTAVA – North American Division
15 Dundonald St., Suite 1902
Toronto, ON M4Y 1K4
Canada
Tel.: 1-416-305-9979
Fax: 1-866-881-9921 (Toll-free in US & Canada)
E-mail: 
http://www.otavachemicals.com |
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