human Fibroblast Growth Factor Receptor 1 inhibitors

yarmoluk · Joined: 27 Feb 2008 Posts: 22 Location: Ukraine

Otava presents a new human Fibroblast Growth Factor Receptor 1 Tyrosine Kinase (FGFR1K) focused library with 1901 compounds

This library has been created as a part of a joint project aimed at design of a large set of receptor-based sharp-focused libraries. In the framework of this project, Life Chemicals provides its Collection of 300 000 compounds and subsequent chemical optimization. Otava provides its In-house Stock Collection (100 000 compounds) and also is responsible for molecular modeling tasks.
Design of the focused libraries consists in Lipinsky/Veber rules filtering and flexible docking in a protein target of certain enzyme family. Further computational analysis for the presence of critical receptor-ligand hydrogen bond(s) and docking score refinement makes our focused libraries good starting point for drug discovery purposes.
In case of this library detection of H-bonding between ligand and key FGFR1K hinge region residue (Ala564) was used for its preparation.
About Otava
Otava supplies Receptor Based and Target Focused compound libraries, custom synthesis, fine chemicals, ProHit compounds, protein kinase inhibitors, combinatorial chemistry templates and building blocks, fluorescent cyanine dyes, Noteworthy Compounds. They offer design and development of fluorescent probes, kits and reagents.
Company contact information:

OTAVA
P.O. Box 88
Kyiv 187, 03187
Ukraine
E-mails:

OTAVA – North American Division
15 Dundonald St., Suite 1902
Toronto, ON M4Y 1K4
Canada
Tel.: 1-416-305-9979
Fax: 1-866-881-9921 (Toll-free in US & Canada)
E-mail:

http://www.otavachemicals.com/